Model Systems & Tools

Research proposing new model systems, tools and assays to study the virus

Published and Preprint Papers

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Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus.

Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection.

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection.

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication.

Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development.

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters.