Drug Targets

Research discussing potential therapeutic coronavirus targets

Published and Preprint Papers

Title

CD14 and CSF1R as developmental molecular targets for the induction of osteoarthritis.

Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation.

SELEX based aptamers with diagnostic and entry inhibitor therapeutic potential for SARS-CoV-2.

The molecular mechanism of non-covalent inhibitor WU-04 targeting SARS-CoV-2 3CLpro and computational evaluation of its effectiveness against mainstream coronaviruses.

Inhibition of the Cellular Deubiquitinase UCHL1 Suppresses SARS-CoV-2 Replication.

Demonstration of the impact of COVID-19 on metabolic associated fatty liver disease by bioinformatics and system biology approach.

Identification of a novel inhibitor of SARS-CoV-2 main protease: an in silico, biochemical, and cell-based approach.

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo.

The nucleotide-sensing Toll-Like Receptor 9/Toll-Like Receptor 7 system is a potential therapeutic target for IgA nephropathy.

Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals.