Introduction: Despite the availability of an effective COVID-19 vaccine, uptake had been low in Midwestern Hispanic communities. A small qualitative study was undertaken to better understand perceptions of COVID-19 disease and prevention among unvaccinated Hispanic adults. Methods: Individual interviews were conducted, in Spanish, with adults ( n = 20) who had not been vaccinated for COVID-19. Interview questions were guided by the Theory of Planned Behavior. Results: Participants ( n = 20) were Hispanic adults (male = 5; female = 15). One overarching theme, lack of trust, emerged from the data. Perceived barriers to vaccination included emotions, personal values and myths. Recommendations by trusted health providers and willingness to receive education emerged as facilitators to COVID vaccine uptake. Conclusion: Members of the XXXX chapter of National Association of Hispanic Nurses used findings from this study to tailor strategies to enhance vaccine confidence in their local community. The chapter partnered with the local health department and Hispanic-serving organizations to provide COVID-19 education and vaccine access.